Human Fibroblast growth factor 5(FGF5) ELISA kit
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中文名稱：人成纖維細(xì)胞生長因子5(FGF5)酶聯(lián)免疫試劑盒
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貨號：CSB-EL008632HU
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規(guī)格：96T/48T
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價格：￥3600/￥2500
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其他：
產(chǎn)品詳情
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產(chǎn)品描述：人成纖維細(xì)胞生長因子5(FGF5)酶聯(lián)免疫試劑盒（CSB-EL008632HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的FGF5含量。FGF5（成纖維細(xì)胞生長因子5）是一種分泌信號蛋白，主要在間充質(zhì)和骨骼肌中表達(dá)。它對哺乳動物毛發(fā)周期性生長起關(guān)鍵作用，同時與動物肢體發(fā)育及人類多形性膠質(zhì)母細(xì)胞瘤、黑色素瘤、肝細(xì)胞癌和高血壓有關(guān)。研究顯示，F(xiàn)GF5通過調(diào)節(jié)細(xì)胞增殖和信號通路影響這些過程。試劑盒檢測范圍為15.6 pg/mL-1000 pg/mL，適用于體外研究場景，如探究FGF5在毛囊生物學(xué)、皮膚病理模型或組織工程中的功能機(jī)制，亦可應(yīng)用于藥物開發(fā)中靶向分子效應(yīng)的評估。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
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別名：FGF 5 ELISA Kit; FGF-5 ELISA Kit; FGF5 ELISA Kit; FGF5_HUMAN ELISA Kit; Fibroblast growth factor 5 ELISA Kit; HBGF 5 ELISA Kit; HBGF-5 ELISA Kit; heparin binding growth factor 5 ELISA Kit; Heparin-binding growth factor 5 ELISA Kit; Smag 82 ELISA Kit; Smag-82 ELISA Kit; TCMGLY ELISA Kit
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縮寫：
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Uniprot No.：
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種屬：Homo sapiens (Human)
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樣本類型：serum, plasma, tissue homogenates
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檢測范圍：15.6 pg/mL-1000 pg/mL
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靈敏度：3.9 pg/mL
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反應(yīng)時間：1-5h
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樣本體積：50-100ul
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檢測波長：450 nm
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研究領(lǐng)域：Signal Transduction
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測定原理：quantitative
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測定方法：Sandwich
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精密度：
Intra-assay Precision (Precision within an assay): CV%<8% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV%<10% Three samples of known concentration were tested in twenty assays to assess. -
線性度：
To assess the linearity of the assay, samples were spiked with high concentrations of human FGF5 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. Sample Serum(n=4) 1:1 Average % 96 Range % 90-100 1:2 Average % 89 Range % 85-93 1:4 Average % 92 Range % 88-96 1:8 Average % 106 Range % 100-113 -
回收率：
The recovery of human FGF5 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section. Sample Type Average % Recovery Range Serum (n=5) 95 89-99 EDTA plasma (n=4) 91 86-97 -
標(biāo)準(zhǔn)曲線：
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. 
pg/ml OD1 OD2 Average Corrected 1000 2.314 2.227 2.271 2.126 500 1.816 1.876 1.846 1.701 250 1.334 1.402 1.368 1.223 125 0.801 0.840 0.821 0.676 62.5 0.544 0.518 0.531 0.386 31.2 0.372 0.359 0.366 0.221 15.6 0.271 0.282 0.277 0.132 0 0.142 0.147 0.145 -
數(shù)據(jù)處理：
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貨期：3-5 working days
引用文獻(xiàn)
- Fibroblast growth factor 5 protects against spinal cord injury through activating AMPK pathway F Chen,Journal of cellular and molecular medicine,2023
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase.
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基因功能參考文獻(xiàn)：
- Study indicated that MTHFR rs1801133, FGF5 rs16998073 and CSK rs1378942 were associated with increased the risk of obesity in the Chinese children. PMID: 30217759
- FGF5 is an independent protective factor for breast cancer patients. PMID: 29804124
- These results provide new insight into the functions of miR-9-3p and HBGF-5 in HCC and identify miR-9-3p as a potential therapeutic target for HCC PMID: 28750499
- FGF5 facilitates cell proliferation through ERK1/2 activation, and it influences the osteogenic differentiation of tonsil-derived mesenchymal stem cells. PMID: 27224250
- These findings collectively demonstrate a tumor suppressor role of miR-188-5p in HCC progression via targeting FGF5 PMID: 25998163
- High BMI increases the effect of the blood pressure-increasing allele at rs1458038 near FGF5 in a Chinese population. PMID: 25618516
- In Chinese children, no association of CSK rs1378942, MTHFR rs1801133, CYP17A1 rs1004467, STK39 rs3754777 and FGF5 rs16998073 with BP/risk of hypertension. PMID: 23759979
- FGF5 is a crucial regulator of hair growth in humans. PMID: 24989505
- Meta-analysis indicated significant associations of both CYP17A1 rs11191548 and FGF5 rs16998073 polymorphisms with hypertension susceptibility in East Asians. PMID: 22959498
- Variants in or near FGF5, CYP17A1 and MTHFR contributed to variation in BP and hypertension risk. Effect sizes of these three loci tended to be larger in Chinese than in white Europeans PMID: 20852445
- variation in FGF5 and ZNF652 gene upstream regions with altered susceptibility to hypertension in Han Chinese PMID: 20542020
- The role of the proteasome is confirmed when a spliced FGF-5 peptide is produced in vitro after incubation of proteasomes with a 49-amino-acid precursor peptide in a transpeptidation splicing model. PMID: 20154207
- FGF5 contributes to the malignant progression of human astrocytic brain tumours by both autocrine and paracrine effects. PMID: 18362893
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相關(guān)疾病：Trichomegaly (TCMGLY)
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亞細(xì)胞定位：Secreted.
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蛋白家族：Heparin-binding growth factors family
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組織特異性：Expressed in neonatal brain.
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數(shù)據(jù)庫鏈接：
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