Human Fibroblast growth factor 18(FGF18) ELISA kit
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中文名稱(chēng):人成纖維細(xì)胞生長(zhǎng)因子18(FGF18)酶聯(lián)免疫試劑盒
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貨號(hào):CSB-EL008623HU
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規(guī)格:96T/48T
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價(jià)格:¥3600/¥2500
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其他:
產(chǎn)品詳情
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產(chǎn)品描述:人成纖維細(xì)胞生長(zhǎng)因子18(FGF18)酶聯(lián)免疫試劑盒(CSB-EL008623HU)為雙抗夾心法ELISA試劑盒,定量檢測(cè)血清、血漿、組織培養(yǎng)上清液、組織勻漿樣本中的FGF18含量。FGF18即成纖維細(xì)胞生長(zhǎng)因子18,在胚胎發(fā)育、組織修復(fù)與再生等過(guò)程發(fā)揮關(guān)鍵作用。研究主要聚焦其信號(hào)通路機(jī)制,它可與特定受體結(jié)合激活下游信號(hào),影響細(xì)胞增殖、分化等活動(dòng),在骨疾病、腫瘤等疾病治療領(lǐng)域有潛在應(yīng)用價(jià)值。試劑盒檢測(cè)范圍為31.25 pg/mL-2000 pg/mL,支持骨骼生物學(xué)研究、軟骨再生機(jī)制探索、藥物篩選模型中FGF18表達(dá)動(dòng)態(tài)監(jiān)測(cè)以及相關(guān)疾病的分子機(jī)制解析等基礎(chǔ)研究領(lǐng)域本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
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別名:FGF 18 ELISA Kit; FGF-18 ELISA Kit; Fgf18 ELISA Kit; FGF18_HUMAN ELISA Kit; FGFI ELISA Kit; Fibroblast growth factor 18 ELISA Kit; zFGF5 ELISA Kit
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縮寫(xiě):
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Uniprot No.:
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種屬:Homo sapiens (Human)
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樣本類(lèi)型:serum, plasma, cell culture supernates, tissue homogenates
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檢測(cè)范圍:31.25 pg/mL-2000 pg/mL
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靈敏度:7.81 pg/mL
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反應(yīng)時(shí)間:1-5h
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樣本體積:50-100ul
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檢測(cè)波長(zhǎng):450 nm
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研究領(lǐng)域:Signal Transduction
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測(cè)定原理:quantitative
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測(cè)定方法:Sandwich
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精密度:
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線(xiàn)性度:
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回收率:
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標(biāo)準(zhǔn)曲線(xiàn):
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數(shù)據(jù)處理:
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貨期:3-5 working days
引用文獻(xiàn)
- FGF18 alleviates hepatic ischemia-reperfusion injury via the USP16-mediated KEAP1/Nrf2 signaling pathway in male mice G Tong,Nature communications,2023
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation.
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基因功能參考文獻(xiàn):
- FGF18 played an important role in the growth and metastasis of breast cancer. PMID: 29901199
- we genotyped rs9313548 and performed case-control-based association analysis with developmental dyslexia in a Chinese population. Our results were in consistent with previous studies as we did not observe significant association of rs9313548 with developmental dyslexia. PMID: 29240020
- the suppressive effect of miR-139 on FGF18 and in turn on proliferation, apoptosis, invasion, migration and tumor-induced angiogenesis of HCC cells was investigated. FGF18 was suggested as a prognostic biomarker and therapeutic target in HCC patients and miR-139 may be a promising strategy used in HCC treatment via the suppression of FGF18 PMID: 28765917
- the results suggest that FGF18 may be involved in MC3T3E1 cell proliferation and osteoblastic differentiation. PMID: 28765932
- significantly increased in endometrioid adenocarinoma PMID: 27267714
- FGF9 and FGF18 increased the migratory capacities of human lung fibroblasts, and FGF9 actively modulated matrix metalloproteinase activity in idiopathic pulmonary fibrosis. PMID: 26773067
- FGF18 serves an essential role in the growth and migration of non-small cell lung cancer cells by regulating the ERK, p38 signaling pathways and MMP26 protein levels. PMID: 27959447
- Data suggest that the combination of FIGO stage, ovarian carcinoma type, and/or fibroblast growth factor 18 (FGF18) score could predict poor prognosis among ovarian carcinoma patients. PMID: 26427667
- The position of sulfate ions bound to FGF18 provides insight into the putative HS-binding site and allows comparison with the prototypical FGFs, FGF1, and FGF2. PMID: 24668462
- role for FGF-18 in chondrogenic and osteogenic events which drive discal development and ossification of the vertebral bodies. PMID: 23397188
- Fgf18 as a molecule that protects articular cartilage by gene expression profiling, and the anticatabolic effects may at least partially be mediated by the Timp1 expression. PMID: 24577103
- Tumors from ovarian cancer patients had increased FGF18 expression levels with microvessel density and M2 macrophage infiltration. PMID: 24018557
- FGF8, FGF17, and FGF18 are involved in autocrine and paracrine signaling in HCC and enhance the survival of tumor cells under stress conditions, malignant behavior, and neoangiogenesis. PMID: 21319186
- There was an association between gene FGF18 rs4043716 and nonsyndromic cleft lip with or without palate in Chinese population. PMID: 19727229
- FGF2 and -18 bind to discrete structures on the heparan sulfate chains attached to chondrocyte-derived perlecan which modulate the growth factor activities PMID: 20507176
- fibroblast growth factor 18 seems to play a role in maintenance of chondrocyte properties, although its expression was rather high in dedifferentiated chondrocytes. PMID: 19909293
- analysis of FGF18 and FGFR5 expression in primary endothelial cells and vascular smooth muscle cells PMID: 16019430
- FGF18 is wildly expressed in the cardiovascular tissue. It enhanced cell migration in response to mechanical damage. we detected FGF18 expression in liver vascular and liver sinusoidal endothelial cells (LSECs), but not in hepatic parenchymal cells. PMID: 16756958
- FGF18 may play a prominent role in chondrogenesis and osteogenesis during skeletal development and growth (review) PMID: 17128416
- FGF3, FGF7, FGF10, FGF18, and FGFR1 may have roles in nonsyndromic cleft lip and palate PMID: 17360555
- FGF18 is almost generally over-expressed in colon cancer and exerts pro-tumorigenic effects both in the epithelial and the stromal compartments by stimulating growth and survival of tumour cells, migration of fibroblasts and neovascularization PMID: 17890768
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亞細(xì)胞定位:Secreted.
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蛋白家族:Heparin-binding growth factors family
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