Human Complement C1q tumor necrosis factor-related protein 9A(C1QTNF9) ELISA kit

Human Complement C1q tumor necrosis factor-related protein 9A(C1QTNF9) ELISA kit

產品詳情

引用文獻

產品評價

靶點詳情

產品詳情

引用文獻

產品評價

相關產品

靶點詳情

Most popular with customers

產品中心

信號通路

技術信息

聯系信息

文獻引用 (2) 說明書下載

中文名稱：

人補體C1q腫瘤壞死因子相關蛋白9A(C1QTNF9)酶聯免疫試劑盒
貨號：

CSB-EL003654HU
規格：

96T/48T
價格：

￥3600/￥2500
其他：

CUSABIO Wins 2024 Bioz Rapid Star? Award in the ELISA category

產品詳情
產品評價
引用文獻
相關產品
靶點詳情

產品描述：

人補體C1q腫瘤壞死因子相關蛋白9A(C1QTNF9)酶聯免疫試劑盒（CSB-EL003654HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的C1QTNF9含量。試劑盒檢測范圍為0.312 ng/mL-20 ng/mL，產品適用于基礎研究領域，例如探究代謝性疾病動物模型的蛋白表達變化、評估炎癥相關信號通路調控機制，或用于體外培養細胞中C1QTNF9分泌水平的動態監測，為疾病機制研究與藥物開發提供可靠工具。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
別名：

C1QTNF9 ELISA kit; C1QTNF9A ELISA kit; UNQ6503/PRO21380Complement C1q and tumor necrosis factor-related protein 9A ELISA kit; Complement C1q and tumor necrosis factor-related protein 9 ELISA kit
縮寫：

C1QTNF9
Uniprot No.：

P0C862
種屬：

Homo sapiens (Human)
樣本類型：

serum, plasma, tissue homogenates
檢測范圍：

0.312 ng/mL-20 ng/mL
靈敏度：

0.078 ng/mL
反應時間：

1-5h
樣本體積：

50-100ul
檢測波長：

450 nm
研究領域：

Others
測定原理：

quantitative
測定方法：

Sandwich

精密度：

線性度：

To assess the linearity of the assay, samples were spiked with high concentrations of human C1QTNF9 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
	Sample	Serum(n=4)
1:1	Average %	97
	Range %	91-101
1:2	Average %	101
	Range %	95-104
1:4	Average %	92
	Range %	85-95
1:8	Average %	100
	Range %	94-103

回收率：

The recovery of human C1QTNF9 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

Sample Type	Average % Recovery	Range
Serum (n=5)	91	85-96
EDTA plasma (n=4)	90	82-94

標準曲線：

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

ng/ml	OD1	OD2	Average	Corrected
20	2.840	2.799	2.820	2.711
10	2.104	1.997	2.051	1.942
5	1.171	1.151	1.161	1.052
2.5	0.532	0.523	0.528	0.419
1.25	0.349	0.358	0.354	0.245
0.625	0.233	0.242	0.238	0.129
0.312	0.161	0.157	0.159	0.050
0	0.111	0.107	0.109

數據處理：

ELISA操作視頻及標曲繪制軟件下載
貨期：

3-5 working days

Serum C1q/TNF-related protein 9 is not related to nonalcoholic fatty liver disease ChiZhang.et al,Cytokine,2018
Association of serum C1q tumour necrosis factor?related protein 9 with the severity of lower extremity peripheral arterial disease in type 2 diabetes patients Jiang W.et al,Diab Vasc Dis Res,2018

功能：

Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways.
基因功能參考文獻：
1. suggesting the protective potentials of C1q tumour necrosis factor-related protein 9 in the progression of peripheral arterial disease in human type 2 diabetes mellitus PMID: 29543038
2. Authors demonstrate that CTRP9 regulates growth, differentiation, and apoptosis of HaCaT human keratinocytes. We found that CTRP9 augmented expression of transforming growth factor beta 1 (TGFbeta1) by transcription factor activator protein 1 (AP-1) binding activity and phosphorylation of p38 in a dose-dependent manner. PMID: 29145717
3. CTRP9 inhibits the cholesterol-induced Vascular smooth muscle cell phenotype switch and cell dysfunction by activating PRKAA1. PMID: 28524645
4. results revealed increased circulating levels of CTRP9 in T2DM and CAD individuals which suggests a compensatory response to insulin resistance, inflammatory milieu and endothelial dysfunction; however, more studies are needed to confirm this PMID: 29381773
5. CTRP9 levels are elevated in obesity and significantly decrease following weight loss surgery. PMID: 26982010
6. Plasma CTRP9 levels are associated with atherosclerosis in diabetic patients without CKD, independently of obesity, adiponectin, and traditional cardiovascular risk factors PMID: 28070523
7. The up-regulation of CTRP9 during hypertrophic heart disease facilitates maladaptive cardiac remodeling and left ventricular dysfunction. PMID: 27821723
8. Results demonstrate that CTRP9 alleviates hepatic steatosis through relief of endoplasmic reticulum stress via the AMPK-mediated induction of autophagy. PMID: 26419929
9. Study demonstrates that CTRP9 attenuates cytokine-induced vascular inflammation in endothelial cells mediated by AMPK activation. PMID: 26523509
10. Circulating and coronary CTRP9 plays an important role in the inflammation and coronary atherosclerosis of CAD patients. Serum CTRP9 is an independent protective factor of CAD PMID: 26457306
11. Serum CTRP9 concentration was significantly and positively associated with arterial stiffness in patients with type 2 diabetes PMID: 25105737
12. Serum CTRP9 concentrations were positively associated with favorable glucose or metabolic phenotypes and absence of metabolic syndrome, independent of serum total adiponectin concentrations. PMID: 24357853
顯示更多

收起更多
亞細胞定位：

Secreted.
組織特異性：

Expressed predominantly in adipose tissue.
數據庫鏈接：

HGNC: 28732

OMIM: 614285

KEGG: hsa:338872

STRING: 9606.ENSP00000333737

UniGene: Hs.362854

Intra-assay Precision (Precision within an assay): CV%<8%

Three samples of known concentration were tested twenty times on one plate to assess.

Inter-assay Precision (Precision between assays): CV%<10%

Three samples of known concentration were tested in twenty assays to assess.