Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense.

1. ceruloplasmin as a biomarker of chronic kidney disease in urine of sickle cell disease patients PMID: 29127684
2. Maternal blood ceruloplasmin level was found to be lower in neural tube defect-affected pregnancies as compared to healthy controls. PMID: 28397206
3. Increased serum transferrin and ceruloplasmin turnover in diet-controlled patients with type 2 diabetes has been reported. PMID: 29079528
4. Strong correlations between the meconium concentrations of CP, LF and MPO indicate a possible role of these complementary proteins in maintaining homeostasis of the intrauterine environment of the fetus. CP, LF and MPO measured in meconium may serve as biomarkers for assessment of impairment of oxidative balance during intrauterine life with its potential impact on disease development in adulthood. PMID: 27903408
5. A woman in her 50s who initially presented with movement disorder was diagnosed with aceruloplasminemia, a rare autosomal recessive disorder resulting in accumulation of iron deposits in major organs. Genetic testing confirmed mutations in the ceruloplasmin gene (c.1864 + 1G>C). PMID: 27416276
6. Higher circulating ceruloplasmin levels were associated with increased atrial fibrillation risk. PMID: 28427851
7. for ATP7B mutations, the more severe impact on ATP7B protein was, the younger onset age and lower Cp level presented. The feasibility of presymptomatic DNA diagnosis and predicting clinical manifestation or severity of Wilson disease (WD) would be facilitated with identified mutations and genotype-phenotype correlation precisely revealed in the study. PMID: 27982432
8. Ceruloplasmin is supposed to be related with advanced T stage and perineural invasion, having a possibility as a candidate prognostic marker for bile duct cancer. PMID: 28423673
9. Mechanistically, ceruloplasmin could specifically interact with the hepatitis B virus middle surface protein. PMID: 28678687
10. The present study determined that ARE, CLP, CAT, and MPO levels are different between the pediatric patients with sepsis and healthy controls. ARE level can be a potent biomarker for sepsis in critical patients in intensive care units. PMID: 28167245
11. Ceruloplasmin was independently and negatively associated with liver fibrosis in chronic hepatitis b. PMID: 27920479
12. Coronary atherosclerosis is distinguished by serum C4 complement up-regulation and ceruloplasmin down-regulation. PMID: 28091899
13. Data show that the concentration of ceruloplasmin (ferroxidase; Cp) was significantly higher in Low hemoglobin (Hb) compared to High Hb subsample. PMID: 27235174
14. serum ceruloplasmin level was lower in the primary open-angle glaucoma group in comparison to the group with only cataract. PMID: 27109647
15. The determination of serum ceruloplasmin in adolescents might be a useful tool to identify patients with the highest risk of future cardiovascular disease. PMID: 27083758
16. The main result of this study is that ceruloplasmin specific activity is associated with a decreased risk of developing Alzheimer's disease PMID: 26836154
17. pathological cerebrospinal fluid's environment of Parkinson's disease patients promoted the same modifications in the exogenously added ceruloplasmin PMID: 26537957
18. Homozygosity for c.1948G>A is described in a Dutch family with aceruloplasminemia. PMID: 25661792
19. Cp-mediated neuroprotection occurs via the inhibition of seizure-associated oxidative damage. PMID: 25843655
20. PON-1 and ferroxidase activities in older patients with mild cognitive impairment, late onset Alzheimer's disease or vascular dementia PMID: 25490030
21. results of this study suggest that common genetic variants of CP are associated with PD and further investigation is needed to explore their functions in Parkinson disease. PMID: 25758665
22. we have through bioinformatic screening identified ceruloplasmin as a novel adipokine with increased expression in adipose tissue of obese subjects as well as in cells from obesity-associated cancers. PMID: 24676332
23. sLe(x)/CP ratio tended to be higher for the pancreatic adenocarcinoma PMID: 25595436
24. brain microvascular endothelial cell -secreted cytokine activity increases the gene expression of neighboring C6 glioma CP, which reciprocally acts on basolateral BMVEC ferroportin to enhance brain iron import PMID: 25311416
25. High ceruloplasmin levels are associated with preeclampsia. PMID: 25463281
26. Mercury metallation of the bacterial copper protein azurin is analogous to the one of human cerulopsmin and factor VIII in mercury poisoning. PMID: 25265377
27. A reduced serum FeOx activity, which can potentially lead to a rise in oxidative stress-induced biomolecular damage, seems to be a shared condition in inflammatory disorders of the central nervous system including MS. PMID: 25398823
28. This review describes the main role of ceruloplasmin in iron turnover is oxidizing Fe2+ into Fe3+, a process which is essential for iron binding to transferrin (the main iron-transporting protein), as well as to ferritin (the main iron-storage protein) PMID: 24988611
29. ceruloplasmin and hepcidin differentially regulate iron efflux from brain microvascular endothelial cells PMID: 24533165
30. The core-fucosylation ratio of ceruloplasmin increases significantly in alcohol-related hepatocellular carcinoma. PMID: 24799124
31. In CKD patients, increased serum ceruloplasmin, a regulator of nitric oxide activity, is associated with increased risk of long-term adverse cardiovascular events, even after multivariable model adjustment for traditional clinical/biologic risk factors. PMID: 24311705
32. Ceruloplasmin and gelsolin are closely interacted with the oncogene NF-kappab. PMID: 23925487
33. Increased urinary excretion of plasma proteins such as IgG, ceruloplasmin and transferrin, with different molecular radii of 55 A or less and different isoelectric points precede development of microalbuminuria in patients with NIDDM and hypertension. PMID: 24256706
34. The main result of this meta-analysis is that copper not bound to ceruloplasmin appears signi fi cantly increased in subjects with Alzheimer's disease when compared to healthy controls. PMID: 24072069
35. CP levels correlate negatively and indirectly with inflammation and fibrosis stages in male chronic hepatitis B patients. PMID: 24282481
36. both Cp NGR sites can deamidate during aging under oxidative conditions, likely as a consequence of oxidative-induced structural changes, thereby promoting a gain of function in integrin binding, signaling, and cell adhesion. PMID: 24366863
37. Findings indicate a causal role of ceruloplasmin in AF pathophysiology and suggest that ceruloplasmin might be a mediator in a specific inflammatory pathway that causally links inflammatory diseases and incidence of Atrial Fibrillation (AF). PMID: 24118451
38. A novel homozygous mutation of c.2185 delC in exon 12 was found in ceruloplasmin gene in a patient with aceruloplasminemia. PMID: 23812204
39. Eosinophil activation occurred in early and late responses after L-ASA NPT in upper airway mucosa of AERD patients, where ApoA1, alpha2M and CP as well as CysLT may be involved in eosinophilic inflammation. PMID: 23786280
40. The diffusion of an Fe(2+) ion from the inner opening of the human H-chain ferritin to a ferroxidase site located in the interior region of the protein coat is assisted by Thr135, His136 and Tyr137. PMID: 23344859
41. Ceruloplasmin was significantly elevated in patients with ischemic or nonischemic cardiomyopathy and had linear correlation with C-reactive protein and LVEF PMID: 23781119
42. Cp was associated with incident heart failure, mortality, and cardiovascular disease in the Atherosclerosis Risk in Communities population. PMID: 23861484
43. Data suggest that ceruloplasmin (CP) level in serum decreases according to severity of pediatric nonalcoholic fatty liver disease (NAFLD); thus, serum CP may serve as biomarker to discriminate children with severe NAFLD. PMID: 23154483
44. plasma ceruloplasmin is a potential plasma biomarker of aGvHD, and it also has prognostic value for risk-adapted prophylaxis. PMID: 23505556
45. Iron efflux from human brain microvasculature endothelial cells ferroportin requires the action of an exocytoplasmic ferroxidase which can be either endogenous hephaestin or extracellular ceruloplasmin. PMID: 23640881
46. study of effect of occupational exposure to lead among metallurgy workers in Poland on blood levels of transferrin (TRF), ceruloplasmin (CER) and haptoglobin (HPG): Data suggest that blood levels of copper and CER are raised with lead exposure. PMID: 22923205
47. ceruloplasmin should provide a protective shield against inadvertent oxidant production by myeloperoxidase during inflammation PMID: 23306200
48. Letter: report mutations in ceruloplasmin promoter in and possible role in iron hemostasis in patients with porphyria cutanea tarda. PMID: 23012398
49. study to determine if genetic variations identified in CP gene contribute to oesophageal cancer (OC) pathogenesis or susceptibility in Black Xhosa-speaking South African population; statistically significant associations found for 2 of the novel variants with OC in this study and could potentially contribute to disease susceptibility PMID: 21901748
50. change of the maintenance of three acute phase proteins: ceruloplasmin, alpha1-antitripsin and orosomucoid in an oral fluid and blood plasma at paradontitis and myocardial infarction PMID: 22708402

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Secreted.

Multicopper oxidase family

Expressed by the liver and secreted in plasma.

HGNC: 2295

OMIM: 117700

KEGG: hsa:1356

STRING: 9606.ENSP00000264613

UniGene: Hs.558314