Human Cardiotrophin-like cytokine factor 1(CLCF1) ELISA kit
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中文名稱：人心臟營養素樣細胞因子1(CLCF1)酶聯免疫試劑盒
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貨號：CSB-EL005479HU
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規格：96T/48T
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價格：￥3600/￥2500
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其他：
產品詳情
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產品描述：人心臟營養素樣細胞因子1(CLCF1)酶聯免疫試劑盒（CSB-EL005479HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織培養上清液、組織勻漿樣本中的CLCF1含量。CLCF1即睫狀神經營養因子樣細胞因子1，在人體生理和病理過程中發揮一定作用。研究聚焦于其參與的細胞信號傳導通路，如與受體結合介導的信號傳遞，探尋其在神經發育、免疫調節及疾病發生發展等方面機制，以助力相關疾病治療靶點開發。試劑盒檢測范圍為0.312 ng/mL-20 ng/mL，該產品可滿足體外實驗中對CLCF1蛋白表達量的精準檢測需求，支持心血管疾病機制研究、炎癥信號通路分析以及藥物開發中的生物標志物探索等科研場景，尤其適用于細胞模型、動物實驗或臨床前研究中相關樣本的定量檢測。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
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別名：B cell stimulating factor 3 ELISA Kit; B-cell-stimulating factor 3 ELISA Kit; BSF 3 ELISA Kit; BSF-3 ELISA Kit; BSF3 ELISA Kit; Cardiotrophin like cytokine ELISA Kit; Cardiotrophin like cytokine factor 1 ELISA Kit; Cardiotrophin-like cytokine factor 1 ELISA Kit; CISS 2 ELISA Kit; CISS2 ELISA Kit; CLC ELISA Kit; CLCF 1 ELISA Kit; Clcf1 ELISA Kit; CLCF1_HUMAN ELISA Kit; Cold induced sweating syndrome 2 ELISA Kit; CRLF 1 associated cytokine like factor 1 ELISA Kit; CRLF1 associated cytokine like factor 1 ELISA Kit; Neurotrophin 1 ELISA Kit; Neurotrophin 1/B cell stimulating factor 3 ELISA Kit; Neurotrophin1 ELISA Kit; NNT 1 ELISA Kit; NNT-1 ELISA Kit; Novel neurotrophin 1 ELISA Kit; Novel neurotrophin-1 ELISA Kit; NR 6 ELISA Kit; NR6 ELISA Kit
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縮寫：CLCF1
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Uniprot No.：
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種屬：Homo sapiens (Human)
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樣本類型：serum, plasma, cell culture supernates, tissue homogenates
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檢測范圍：0.312 ng/mL-20 ng/mL
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靈敏度：0.078 ng/mL
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反應時間：1-5h
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樣本體積：50-100ul
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檢測波長：450 nm
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研究領域：Others
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測定原理：quantitative
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測定方法：Sandwich
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數據處理：
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貨期：3-5 working days
產品評價
相關產品
靶點詳情
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功能：In complex with CRLF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable). Also stimulates B-cells. Binds to and activates the ILST/gp130 receptor.
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基因功能參考文獻：
- CLF-1, based on its binding site for CLC and on two additional and independent sites for CNTFRalpha and sorLA, is a key player in CLC and CNTFRalpha signaling and turnover. PMID: 26858303
- Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP) signalling and their roles in development, adulthood, cancer and degenerative disorders. PMID: 26198769
- albuminuria in focal segmental glomerulosclerosis is related to qualitative or quantitative changes in the CLCF1-CRLF1 complex. PMID: 25843671
- activation of the Jak-STAT cascade is essential for corticotroph NNT-1/BSF-3 signaling. PMID: 12639901
- Structural and docking interaction studies showed that the R197L substitution destabilized the contact site between CLC and CNTFRalpha. PMID: 16782820
- Ciliary neurotrophic factor, cardiotrophin-like cytokine, and neuropoietin share a conserved binding site on the ciliary neurotrophic factor receptor alpha chain PMID: 18728012
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相關疾病：Cold-induced sweating syndrome 2 (CISS2)
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亞細胞定位：Secreted.
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蛋白家族：IL-6 superfamily
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組織特異性：Expressed predominantly in lymph nodes, spleen, peripheral blood lymphocytes, bone marrow, and fetal liver.
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數據庫鏈接：
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