Human C1q/TNF-related protein-3,Cartonectin/CTRP3/CORS-26 ELISA Kit
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中文名稱(chēng)：人C1q/TNF相關(guān)蛋白3(Cartonectin/CTRP3/CORS-26)酶聯(lián)免疫試劑盒
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貨號(hào)：CSB-E13426h
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規(guī)格：96T/48T
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價(jià)格：￥3600/￥2500
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其他：
產(chǎn)品詳情
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產(chǎn)品描述：人C1q/TNF相關(guān)蛋白3(Cartonectin/CTRP3/CORS-26)酶聯(lián)免疫試劑盒（CSB-E13426h）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織培養(yǎng)上清液樣本中的C1QTNF3含量。C1q/TNF相關(guān)蛋白3（CTRP3）是一種分泌蛋白，屬于CTRP家族，具有多種生理功能。研究發(fā)現(xiàn)，CTRP3在代謝、炎癥和生存信號(hào)傳導(dǎo)等方面發(fā)揮重要作用，與肥胖、2型糖尿病、心血管疾病等代謝相關(guān)疾病密切相關(guān)。試劑盒檢測(cè)范圍為0.156 ng/mL-10 ng/mL，該產(chǎn)品適用于細(xì)胞生物學(xué)、基礎(chǔ)醫(yī)學(xué)等科研領(lǐng)域，可用于探究CTRP3在代謝性疾病模型中的表達(dá)調(diào)控機(jī)制、炎癥相關(guān)信號(hào)通路研究，或評(píng)估藥物干預(yù)對(duì)靶蛋白分泌水平的影響，為相關(guān)疾病的分子機(jī)制研究提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
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別名：C1ATNF3 ELISA Kit; C1q and tumor necrosis factor related protein 3 ELISA Kit; C1QT3_HUMAN ELISA Kit; C1qtnf3 ELISA Kit; Cartonectin ELISA Kit; Collagenous repeat containing sequence of 26 kDa ELISA Kit; collagenous repeat-containing sequence 26 kDa protein ELISA Kit; Complement C1q tumor necrosis factor related protein 3 ELISA Kit; Complement C1q tumor necrosis factor-related protein 3 ELISA Kit; Corcs ELISA Kit; CORS 26 ELISA Kit; Cors ELISA Kit; CORS26 ELISA Kit; CTRP3 ELISA Kit; FLJ37576 ELISA Kit; OTTHUMP00000115918 ELISA Kit; OTTHUMP00000219981 ELISA Kit; PRO1484 ELISA Kit; Secretory protein CORS26 ELISA Kit; UNQ753 ELISA Kit
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縮寫(xiě)：C1QTNF3
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Uniprot No.：
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種屬：Homo sapiens (Human)
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樣本類(lèi)型：serum, plasma, cell culture supernates
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檢測(cè)范圍：0.156 ng/mL-10 ng/mL
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靈敏度：0.039 ng/mL
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反應(yīng)時(shí)間：1-5h
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樣本體積：50-100ul
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檢測(cè)波長(zhǎng)：450 nm
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研究領(lǐng)域：Others
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測(cè)定原理：quantitative
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測(cè)定方法：Sandwich
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精密度：
Intra-assay Precision (Precision within an assay): CV%<8% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV%<10% Three samples of known concentration were tested in twenty assays to assess. -
線(xiàn)性度：
To assess the linearity of the assay, samples were spiked with high concentrations of human CTRP3 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. Sample Serum(n=4) 1:1 Average % 88 Range % 81-95 1:2 Average % 92 Range % 90-102 1:4 Average % 96 Range % 91-100 1:8 Average % 95 Range % 89-102 -
回收率：
The recovery of human CTRP3 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section. Sample Type Average % Recovery Range Serum (n=5) 93 85-100 EDTA plasma (n=4) 101 90-110 -
標(biāo)準(zhǔn)曲線(xiàn)：
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. 
ng/ml OD1 OD2 Average Corrected 10 1.839 1.952 1.896 1.741 5 1.616 1.586 1.601 1.446 2.5 1.354 1.271 1.313 1.158 1.25 0.912 0.932 0.922 0.767 0.625 0.617 0.609 0.613 0.458 0.312 0.412 0.388 0.400 0.245 0.156 0.263 0.251 0.257 0.102 0 0.159 0.151 0.155 -
數(shù)據(jù)處理：
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貨期：3-5 working days
引用文獻(xiàn)
- Plasma levels of CTRP-3, CTRP-9 and apelin in women with multiple sclerosis AmirRasooli Tehrani,Journal of Neuroimmunology,2019
- Possible association between circulating CTRP3 and knee osteoarthritis in postmenopausal women Zhila Maghbooli.et al,Aging Clinical and Experimental Research,2018
- Effect of Aerobic Training on Serum Adiponectin and Ctrp-3 in Males with Metabolic Syndrome Dr Karim Azali Alamdar.et al,Iranian Journal of Endocrinology and metabolism,2017
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靶點(diǎn)詳情
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基因功能參考文獻(xiàn)：
- we have developed a diagnostic and prognostic prediction model for Prostate cancer. C1QTNF3 was revealed as a promising biomarker for Prostate cancer PMID: 29861410
- CTRP3 may be a promising therapeutic target for the treatment of liver fibrosis. PMID: 28320106
- Elevated serum CTRP 3 levels were closely related to the prevalence and severity of coronary artery disease, suggesting that it might be regarded as a novel biomarker for CAD. PMID: 28754090
- defensive roles in suppressing inflammation and fibrosis in polymeric IgA complex-stimulated mesangial cells; may target the NF-kappaB and TGF-beta/Src-Smad3 signaling pathways to play multipotent roles in relieving the pathological progression of IgA nephropathy PMID: 27309491
- CTRP3 promotes mitochondrial biogenesis in cardiomyocytes via AMPK/PGC-1alpha pathway. PMID: 27793739
- Low CTRP3 expression is associated with diabetic retinopathy. PMID: 28632765
- decreased levels of CTRP3 and especially CTRP13 were associated with increased risk of T2DM and CAD PMID: 28033351
- both plasma CTRP-3 and HMGB-1 levels were significantly associated with pre-diabetes mellitus and newly diagnosed type 2 diabetes after adjusting for several confounders PMID: 27738641
- This research suggested that CTRP3 might protect chondrocytes against IL-1beta-induced osteoarthritis in a cell model by suppressing the FGFR1- Ras/PI3K/Akt signaling-mediated growth inhibitory pathway. PMID: 27930985
- CTRP3 could improve insulin sensitivity of insulin resistant 3T3-L1 adipocytes by decreasing inflammation and ameliorating insulin signalling transduction, indicating that CTRP3 may be a new target for the prevention and cure of insulin resistance and type 2 diabetes. PMID: 25185846
- CTRP3 is present in cord blood and might be involved in fetal growth PMID: 26656444
- CTRP3 overexpression altered chemokine levels and attenuated systemic inflammation in the setting of obesity. PMID: 26997632
- Lower Circulating C1q/TNF-Related Protein-3 (CTRP3) Levels Are Associated with Obesity PMID: 26222183
- plasma CTRP-3 is strongly associated with glucose and lipid metabolism, chronic inflammation, and insulin resistance. PMID: 26073386
- Results show that cartonectin may serve as a novel biomarker for the prediction and early diagnosis of type 2 diabetes mellitus patients. PMID: 25409499
- Patients with acute coronary syndrome or stable angina pectoris had significantly lower circulating CTRP-3 concentrations compared to controls. PMID: 24417980
- CTRP3 promotes vascular calcification by enhancing phosphate-induced osteogenic transition of VSMC through reactive oxygen species-extracellular signal-regulated kinase 1/2-Runx2 pathway. PMID: 24578384
- Data suggest that serum/omental adipose tissue (AT) cartonectin levels are lower in women with polycystic ovary syndrome; treatment with a hypoglycemic agent (metformin) increases serum cartonectin levels in these women and in omental AT explants. PMID: 24152681
- Data suggest that CTRP3 is expressed in subcutaneous and visceral adipocytes; CTRP3 appears to play important roles in adipocyte (epinephrine-induced) lipolysis, inflammation/infection, and adipokine/resistin secretion. PMID: 23174996
- Data suggest that patients exhibit significantly elevated circulating CTRP-3 in type 2 diabetes or prediabetes compared with subjects with normal glucose tolerance. Plasma CTRP-3 might be useful biomarker for atherosclerosis. PMID: 22837306
- This study provides the first functional evidence linking CTRP3 to hepatic glucose metabolism and establishes CTRP3 as a novel adipokine. PMID: 20952387
- CTRP-3 inhibits three basic and common proinflammatory pathways involved in obesity and type 2 diabetes mellitus (adipo-inflammation) by acting as an endogenous LPS antagonist of the adipose tissue. PMID: 20739398
- Genotyping of the shared variants in a Puerto Rican sample of 118 cases and 136 controls did not reveal either allelic or genotype association with schizophrenia. PMID: 20483475
- Blood level is determined by a glucose tolerance test in normal adults PMID: 17311679
- CTRP3/cartducin may be involved as a novel angiogenic factor in the formation of neointima following angioplasty. PMID: 17534697
- CORS26/cartonectin is a new adipokine that differentially regulates the secretion of classical adipokines, with marked differences between the human and the murine systems. PMID: 18421280
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亞細(xì)胞定位：Secreted.
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組織特異性：Expressed in colon and small intestine.
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