Human Bone morphogenetic protein 8B(BMP8B) ELISA kit

Human Bone morphogenetic protein 8B(BMP8B) ELISA kit

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中文名稱：

人骨形態發生蛋白8B(BMP8B)酶聯免疫試劑盒
貨號：

CSB-EL002746HU
規格：

96T/48T
價格：

￥3600/￥2500
其他：

CUSABIO Wins 2024 Bioz Rapid Star? Award in the ELISA category

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產品描述：

人骨形態發生蛋白8B(BMP8B)酶聯免疫試劑盒（CSB-EL002746HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的BMP8B含量。BMP8B屬于骨形態發生蛋白家族成員。在背景上，它參與多種生理進程。研究機制方面，其能調控細胞的增殖、分化和凋亡等，在骨代謝、生殖系統等方面發揮作用，深入研究它對理解相關生理病理過程有重要意義。試劑盒檢測范圍為9.37 pg/mL-600 pg/mL，該產品適用于體外研究BMP8B在骨代謝調控機制、生殖系統功能分析或特定病理模型（如骨發育異常、組織纖維化等）中的動態表達特征，為探索其分子作用機制提供可靠工具。實驗操作流程簡便，兼容常規實驗室設備，支持多樣本類型分析，尤其適用于需要高靈敏度檢測的細胞或動物模型研究。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
別名：

BMP-8 ELISA Kit; BMP-8B ELISA Kit; BMP8 ELISA Kit; Bmp8b ELISA Kit; BMP8B_HUMAN ELISA Kit; bone morphogenetic protein 8 (osteogenic protein 2) ELISA Kit; Bone morphogenetic protein 8 ELISA Kit; Bone morphogenetic protein 8B ELISA Kit; dJ118J21.1 (bone morphogenetic protein 8 (osteogenic protein 2)) ELISA Kit; OP-2 ELISA Kit; OP2 ELISA Kit; Osteogenic protein 2 ELISA Kit
縮寫：

BMP8B
Uniprot No.：

P34820
種屬：

Homo sapiens (Human)
樣本類型：

serum, plasma, tissue homogenates
檢測范圍：

9.37 pg/mL-600 pg/mL
靈敏度：

2.34 pg/mL
反應時間：

1-5h
樣本體積：

50-100ul
檢測波長：

450 nm
研究領域：

Signal Transduction
測定原理：

quantitative
測定方法：

Sandwich

精密度：

線性度：

To assess the linearity of the assay, samples were spiked with high concentrations of human BMP8B in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
	Sample	Serum(n=4)
1:5	Average %	94
	Range %	90-98
1:10	Average %	88
	Range %	82-94
1:20	Average %	103
	Range %	99-108
1:40	Average %	95
	Range %	90-100

回收率：

The recovery of human BMP8B spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

Sample Type	Average % Recovery	Range
Serum (n=5)	96	92-100
EDTA plasma (n=4)	98	94-103

標準曲線：

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

pg/ml	OD1	OD2	Average	Corrected
600	2.056	2.205	2.131	2.008
300	1.607	1.724	1.666	1.543
150	1.102	1.075	1.089	0.966
75	0.645	0.603	0.624	0.501
37.5	0.394	0.373	0.384	0.261
18.75	0.291	0.302	0.297	0.174
9.37	0.187	0.201	0.194	0.071
0	0.120	0.125	0.123

數據處理：

ELISA操作視頻及標曲繪制軟件下載
貨期：

3-5 working days

Circulatory bone morphogenetic protein (BMP) 8B is a non-invasive predictive biomarker for the diagnosis of non-alcoholic steatohepatitis (NASH) N Mounika,PloS one,2023
The Relationship of Antipsychotic Treatment with Reduced Brown Adipose Tissue Activity in Patients with Schizophrenia PY Chen,Psychoneuroendocrinology,2023
Recombinant human bone morphogenetic protein 2 and 7 inhibit the degeneration of intervertebral discs by blocking the Puma-dependent apoptotic signaling S Xie,International Journal of Biological Sciences,2021
Hormonal Profile of Follicular Fluid between Mild Stimulation and Controlled OvarianHyperstimulation IVF Cycles in POR Patients LI Ting-ting.et al,J SUN Yat-sen Univ,2018

功能：

Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.
基因功能參考文獻：
1. Acetylated H3K9 and H4K16 levels at BMP8B were increased in gastric cancer (GC) compared to nontumors (P < 0.05). However, reduced levels of acetylated H3K9 and H4K16 were associated with poorly differentiated GC (P < 0.05). PMID: 27748538
2. Study found that BMP8B was downregulated in pancreatic cancer tissues and BMP8B mediates the survival of pancreatic cancer cells and regulates the progression of pancreatic cancer. PMID: 25176058
3. Five novel SNPs within BMP8B gene.Genetic variants in BMP8B gene are associated with growth traits in Chinese native cattle. PMID: 24076131
4. Epigenetic silencing of the bone morphogenetic protein 2 gene through methylation is associated with gastric carcinomas PMID: 16314833
5. Reports on the mouse homolog of this gene. PMID: 9070944
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亞細胞定位：

Secreted.
蛋白家族：

TGF-beta family
數據庫鏈接：

HGNC: 1075

OMIM: 602284

KEGG: hsa:656

STRING: 9606.ENSP00000361915

UniGene: Hs.734367

Intra-assay Precision (Precision within an assay): CV%<8%

Three samples of known concentration were tested twenty times on one plate to assess.

Inter-assay Precision (Precision between assays): CV%<10%

Three samples of known concentration were tested in twenty assays to assess.