PHOSPHO1 Antibody

文獻引用 (4) 說明書

中文名稱：

磷酸化1兔多克隆抗體
貨號：

CSB-PA819461LA01HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA819461LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA819461LA01HU at dilution of 1:100
其他：

產(chǎn)品詳情
產(chǎn)品評價
引用文獻
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) PHOSPHO1 Polyclonal antibody
Uniprot No.：

Q8TCT1
基因名：

PHOSPHO1
別名：

PHOP1_HUMAN antibody; Phosphatase orphan 1 antibody; Phospho 1 antibody; phospho1 antibody; Phosphoethanolamine/phosphocholine phosphatase antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Phosphoethanolamine/phosphocholine phosphatase protein (1-267AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產(chǎn)品，PHOSPHO1 Antibody (CSB-PA819461LA01HU)，的標記方式是Non-conjugated。對于PHOSPHO1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA819461LB01HU	PHOSPHO1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA819461LC01HU	PHOSPHO1 Antibody, FITC conjugated
Biotin	CSB-PA819461LD01HU	PHOSPHO1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

引用文獻

Histochemical analysis of osteoclast and osteoblast distributions on hydroxyapatite/collagen bone-like nanocomposite embedded in rat tibiae M Sakakibara, T Hasegawa,Journal of Oral Biosciences,2025
Histochemical assessment of the femora of Spontaneously Diabetic Torii-Leprfa (SDT-fa/fa) rats that mimic type II diabetes Q Yao, K Tsuboi, H Hongo, M Sakakibara,Journal of Oral Biosciences,2024
Abaloparatide promotes bone repair of vertebral defects in ovariectomized rats by increasing bone formation A Makino,Bone,2024
Differential osteoblastic activity in primary metaphyseal trabecular and secondary trabeculae of c-fos deficient mice T Yamamoto,Journal of oral biosciences,2023

產(chǎn)品評價

靶點詳情

功能：

Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization. Acts in a non-redundant manner with PHOSPHO1 in skeletal mineralization: while PHOSPHO1 mediates the initiation of hydroxyapatite crystallization in the matrix vesicles (MVs), ALPL/TNAP catalyzes the spread of hydroxyapatite crystallization in the extracellular matrix.
基因功能參考文獻：
1. CpG sites located in PHOSPHO1 gene showed differential methylation in association with lipid traits. Genetic variants in PHOSPHO1 gene were also associated with lipid profile. PMID: 28173150
2. DNA methylation at the PHOSPHO1 locus cg02650017 in blood DNA was associated with a decreased risk for future type 2 diabetes. PMID: 27148772
3. REVIEW: role of bone-type tissue-nonspecific alkaline phosphatase and PHOSPO1 in vascular calcification PMID: 24533943
4. Models of PHOSPHO2 and PHOSPHO1 suggest subtle differences in the charge distributions around the putative substrate entry site and in the location of potential H-bond donors. PMID: 16054448
5. The identification of a novel, alternatively spliced PHOSPHO1 transcript (PHOSPHO1-3a), was described. PMID: 18471996
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亞細胞定位：

Extracellular vesicle.
蛋白家族：

HAD-like hydrolase superfamily, PHOSPHO family
組織特異性：

Expressed at sites of mineralization in bone and cartilage. Highly expressed in osteoblast cell line SaOS-2 which produces a mineralized matrix, but not in MG-63 cell line, which do not mineralize.
數(shù)據(jù)庫鏈接：

HGNC: 16815

KEGG: hsa:162466

STRING: 9606.ENSP00000406909

UniGene: Hs.405607

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